Atalanta scored twice in four minutes to deliver a surprise victory over Liverpool and blow qualification from Champions League Group D wide open.
A much-changed Reds side lacked fluidity and failed to have a shot on target at Anfield on Wednesday.
Josip Ilicic and Robin Gosens struck for the Serie A side midway through the second half.
Mohamed Salah, returning to the side, had fired over with the Reds' best chance in the first half.
The Italian outfit looked more likely to break the deadlock and did so when Ilicic poked beyond Alisson from Alejandro Gomez's teasing cross.