Thiago Alcantara and Joel Matip will miss Liverpool's Premier League encounter with West Ham United, Jürgen Klopp confirmed.
Thiago continues to be sidelined with the hamstring issue he sustained during the warm-up for the Carabao Cup final, while Matip is suffering from illness.
Curtis Jones and Naby Keita will be assessed ahead of Saturday's 5.30pm GMT kick-off at Anfield.
Roberto Firmino, meanwhile, is closing in on a return to full training after his muscle injury.
Klopp told a press conference: “So, you’re right, strength in depth is really important, no doubt about that, especially when you have to play different competitions.