The right-back was part of a Liverpool matchday squad for the first time this season last weekend, remaining on the bench during the 2-1 win over Crystal Palace.
Asked if Clyne is in contention for selection at the moment, Klopp told Liverpoolfc.com: “Of course.
“The only problem we have is that Clyney has been a long time without football; he had games with the U23s but not all week or whatever, it was in the last one or two months.
“Physically, he is fit – but he has no football rhythm, to be honest.
“It’s a very special game tomorrow night and a very demanding opponent, especially for defenders.