The Reds lead the Champions League last-16 tie 5-0 ahead of the second leg after an emphatic victory in the opening meeting in Portugal in February.
Joe Gomez, Adam Lallana, Joel Matip, James Milner and Alberto Moreno have been brought into the starting XI as Klopp utilises the ‘whole quality’ available to him.
“It’s really about bringing in the full quality we have,” the manager explained of his changes.
“We can talk about Trent Alexander-Arnold, who has played four games in a row, quite intense, and played really well. But Joe Gomez is fit and a fantastic player.