Rafael Camacho and Curtis Jones make their senior debuts in the FA Cup third-round tie at Molineux, with only Dejan Lovren and James Milner remaining from the XI that started at Manchester City last time out.
Henderson, Lallana and Van Dijk are not part of the squad as precautions due to minor injuries, revealed Klopp, who also confirmed Fabinho will start at centre-back.
“I had to make these changes. A few players were really ill and then in the last session yesterday we lost Adam Lallana with a minor thing, but it’s enough not [to be able] to play – and Hendo had something from the Man City game,” he said.