The 32-year-old, who skippers the Reds at the Vitality Stadium, is deployed in a defensive role, with Trent Alexander-Arnold named on the bench.
Klopp explained: “It’s no problem. I thought it could be a problem, but obviously he would have even played goalkeeper in game number 500!
“We need to be flexible, all of us, in the period – different positions, different jobs to do in the games. But it’s only slightly different and Millie knows it from his time at left-back.
“We are a very offensive-orientated team, which means he is very often in a comfortable area.