For the first time in 16 years, the Merseyside Derby will contest two sides aiming for a Champions League spot.
Premier League champions Liverpool have suffered a recent drop-off in the league and currently lie in sixth, one place above City rivals Everton who are enjoying a promising resurgence under Carlo Ancelotti.
With three points separating the Merseyside rivals ahead of Saturday evening's clash, Sportsmail puts together a combined Liverpool-Everton XI from those available to play this weekend...
GOALKEEPER - Alisson (Liverpool)
Perhaps the most difficult position to call.