The Reds progressed to the tournament’s last eight after a goalless stalemate with FC Porto at Anfield confirmed a 5-0 aggregate victory for Jürgen Klopp’s men.
They will discover their next opponents in the competition on Friday March 16 ahead of a two-legged tie in early April, but Henderson has no preference.
“It doesn’t matter,” he told BT Sport. “They are all big teams and good teams. Whoever you get, you’ve got to be prepared to go and win. So it doesn’t matter. We’ll be ready.
“This is the business end of the season. The next few months are very important for us as a team, we’ve got some big games coming up.