Hunter Street will be closed from 7pm on Friday, September 13, until 6am on Monday, September 16, due to works taking place as part of the removal of the footbridges under the flawed Churchill Way flyovers.
The works will have a considerable impact on traffic arriving into Liverpool from the M62 and from the north of the city via Scotland Road (A59).
The closure will also cut off access to the Birkenhead (Queensway) Tunnel for traffic coming into Liverpool from the M62 and Islington direction.
Road diversions will be in place around the city centre and congestion is expected before and after the match.