The Reds take a 2-0 lead to Portugal after goals from Naby Keita and Roberto Firmino secured victory in the first leg at Anfield.
Jürgen Klopp's men won 5-0 at Porto in the last 16 of the competition last term and Liverpool are unbeaten in seven meetings with Os Dragoes.
Here are three key battles that could decide the outcome tonight...
Pepe v Sadio Mane
Suspended for the first clash at Anfield, veteran centre-back Pepe is expected to return to the heart of Porto's defence and brings a wealth of experience with him.