The Reds travel to the home of their neighbours aiming to maintain control of the Premier League title race, in the 233rd edition of the rivalry.
And we've picked out three key battles that could help decide the latest meeting with the Toffees...
Lucas Digne v Mohamed Salah
Brought in from Barcelona in the summer, Lucas Digne has superseded veteran defender Leighton Baines as Marco Silva's first-choice left-back.
No Everton defender has made more appearances than Digne's 27 this season and the Frenchman is widely considered to have been the club's standout performer.