Manchester United play their 44th game of a crowded season with manager Erik ten Hag warning the importance of every match will increase from here.
United return to the Premier League on Sunday after their 7-0 humiliation against Liverpool with opponents Southampton motivated by their own scrap against relegation.
Ten Hag has seen his men gamely fight for trophies on four fronts this season, but with the Carabao Cup already won, they ran out of steam at the wrong time at Anfield.
The midweek bounceback against Real Betis was impressive but Ten Hag is adamant there can be no let up.