An U21s squad will represent the Reds against Wigan Athletic in their first group game of the competition tonight.
The behind-closed-doors fixture will be played at the DW Stadium, with kick-off set for 7pm BST.
Lewtas' charges are also set to meet Tranmere Rovers and Port Vale in the section, with teams facing each other once only.
As an invited club from the Premier League, Liverpool are scheduled to play all of their group matches away from home.
The winners and runners-up in each pool for both the northern and southern sections will progress to the last 32, with the tournament then undertaking a knockout format.