Former LFC boss Roy Hodgson sits in the dugout at the south London club, and there could be three ex-Reds lining up against their former employers, too.
Seventeen players to have donned the colours of both clubs down the years and, ahead of this weekend's clash, we've picked out 10 of the best....
Nathaniel Clyne
Crystal Palace: 137 games, 1 goal
Liverpool: 93 games, 2 goals
South London-born Nathaniel Clyne began his career at Crystal Palace, with manager Neil Warnock handing the full-back his debut as a 17-year-old.