David Luiz will make his first start for Chelsea since rejoining the club in a £34m switch from Paris Saint-Germain.
He replaces captain John Terry, who suffered an ankle ligament injury against Swansea last weekend.
Liverpool defender Dejan Lovren is expected to return against Chelsea after missing Saturday's 4-1 win over Leicester because of a bruised eye.
There could be a recall for Philippe Coutinho, who was rested for that game after a long flight from Brazil.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Liverpool's tricky early run of fixtures continues, with unbeaten Chelsea certain to be fired up for this one after dropping points for the first time this season in last Sunday's 2-2 with Swansea.