Brighton left-back Pervis Estupinan faces at least a month out with a muscular issue.
Adam Lallana and James Milner are likely to miss the clash with their former employers due to minor injuries.
Liverpool are without the suspended Curtis Jones and Diogo Jota after the pair were both sent off last weekend.
Forward Cody Gakpo sustained a knee injury in the defeat at Tottenham and he will join Stefan Bajcetic and Thiago on the sidelines.
MATCH FACTS
Head-to-head
- Brighton have won the past two meetings in all competitions, with both victories coming at the Amex Stadium in January.