Ahead of tonight's showdown at Estadio Metropolitano, we have picked out three individual battles to keep an eye on as Atletico Madrid and Liverpool face off.
The opening instalment of the sides’ Champions League last-16 tie sees the Reds return to the venue of their sixth European Cup triumph last June.
Led by the vastly experienced and wily Diego Simeone, an evolving Atletico are aiming to emulate their runs to the competition’s final in 2014 and 2016.
Here are three duels that could prove influential in Spain...
Alvaro Morata v Virgil van Dijk
Alvaro Morata, on loan from Chelsea, made a welcome return for Los Rojiblancos in Friday’s 2-2 La Liga draw with Valencia, entering the game in the 66th minute after missing his side’s previous match.