Aston Villa will head to France next week with a slender advantage and 90 minutes away from a first major European semi-final since 1982.
Goals from Ollie Watkins and John McGinn in either half gave Villa a two-goal lead and they had keeper Emiliano Martinez to thank for an array of crucial saves before Lille pulled one back late on through Bafodo Diakite.
On a night where defeats for Liverpool and West Ham in the Europa League hampered the Premier League’s bid for five Champions League spots - which may prove crucial for Villa - Unai Emery’s side will know they will have their work cut out for the return leg with Paulo Fonseca’s team guilty of not taking their chance.