Adam Lallana's Liverpool reunion lasted just eight minutes with the Brighton midfielder suffering another injury setback.
Lallana started on the bench but was brought on by Seagulls' boss Graham Potter in the 63rd minute, just after Liverpool had taken the lead through Diego Jota.
The former Reds man had barely had a touch of the ball before he was running down the tunnel to be replaced by Alireza Jahanbakhsh.
The midfielder had been a doubt ahead of the game after picking up a groin injury in Brighton's victory over Aston Villa last weekend.