From a magnificent seven in 1978 through to clinching a league title, the Reds have enjoyed some memorable wins over the Londoners.
Remember these?
September 2, 1978: Liverpool 7-0 Tottenham
Tottenham had Argentina World Cup-winners Ricky Villa and Ossie Ardiles in their ranks, but the Reds produced a vintage display that included one of the greatest goals ever seen at Anfield. Kenny Dalglish and David Johnson both scored twice with Ray Kennedy and Phil Neal also on the mark.
The seventh goal was the icing on the cake. It came at the Anfield Road end and was scored by Terry McDermott.