Heading into this knockout tie, the young Reds have won six games in a row - netting 22 goals in the process - and after Monday night's 4-0 win over Accrington Stanley in the FA Youth Cup confidence is high.
However, United beat the Reds 3-1 in the second game of the season in Kirkby and Lewtas insists his players learned a valuable lesson that day.
Kick-off at the Academy is at 11am GMT and you can watch the game live on LFCTV GO with our single-camera coverage.
Read Lewtas' thoughts on the clash, the recent good form of his side, and players getting their chance to move up to U23 level, below.