As domestic football resumes this weekend, the Reds are the first team in action when they face Crystal Palace at Selhurst Park tomorrow lunchtime.
A win in south London would move Karius and co 10 points clear of fifth-placed Chelsea, who on Sunday take on the team one position above them in the table: Tottenham Hotspur.
“It would give us [a] 10-point [lead], which is a good thing. It can’t be negative, a good result can only be positive,” the German told Premier League Productions.
“And of course it is also a little boost for the Manchester City game [in the Champions League].