Kick-off is at 7pm, but for the best build-up join Steve Hothersall alongside former Academy graduates Neil Mellor and Stephen Warnock.
With Michael Beale having left the club, U23s coach Mike Garrity and head of development analysis Tim Jenkins will take charge of the side.
This will be the first time this season that the young Reds get the opportunity to play in front of the Kop and they will hope to replicate their performance at the Emirates in August, when Ben Woodburn scored twice in a 3-1 win over the Gunners.
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