Kick-off is at 7pm, but for comprehensive build-up join former Reds striker Neil Mellor from 6.30pm.
Neil Critchley's side finished third in the northern section of the division during the first half of the season, earning a place in Group 1 for the competition's second stage which will determine who will finish as U18s champions.
After tonight's opening clash with United, the young Reds will also compete with Blackburn Rovers, West Ham United, Reading, Arsenal, Chelsea and Manchester City across the remainder of the campaign.
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