Gomez played the full 90 minutes in Michael Beale's side's 4-0 Lancashire Senior Cup win over Burnley last Wednesday, and the 19-year-old is set to take another step forward in his recovery from a serious knee injury at the iPro Stadium.
Kick-off is at 7pm, but for the best build-up join Rob Jones and former Reds defender Dominic Matteo from 6.30pm.
The U23s, currently third in Premier League 2, will aim to keep up their great form and maintain pressure on Everton and Manchester City.
Liverpool team in full: Grabara, Whelan, Juanma, Gomez, Sakho, Ilori, Wilson, Chirivella, Lennon, Virtue, Brannagan.