Newly promoted Brentford launch the 2021-22 Premier League season when they host Arsenal on Friday (20:00 BST) - the first of 380 matches over the next nine months.
Champions Manchester City, who have smashed the British transfer record to sign Jack Grealish from Aston Villa for £100m, begin their title defence at Tottenham on Sunday (16:30).
"This season is going to be one of the strongest Premier League seasons," said Ole Gunnar Solskjaer, manager of last season's runners-up Manchester United.
"Anyone who ends up above last year's champions will be champions."
For the first time in 17 months, capacity crowds will be allowed following the easing of coronavirus restrictions.