The match at the Kirkby Academy is scheduled to kick-off at 11am and will be shown on LFCTV GO with our single-camera coverage.
Barry Lewtas' side beat Stoke City 4-2 in their opening U18s Premier League Cup Group B game while Reading lost 2-1 at home to Southampton.
The six group winners and two best runners-up will progress to the quarter-final of the competition.