Tottenham make the trip to Belgium to take on Royal Antwerp in Europa League action as Jose Mourinho's men look to stay top of their group.
Spurs opened their campaign with a 3-0 win over LASK at White Hart Lane and will start Gareth Bale as they seek to take control of their group in front of a Belgian side who also won their opening match against Ludogorets
Leicester City are also among the early games kicking off at 5.55pm as they visit Greek side AEK while Scottish champions Celtic take on Lille.