Leeds United forward Rodrigo is set to be out for up to two months with an ankle injury.
Rodrigo, 31, who signed from Valencia for £26m in August 2020, is his side's top scorer with 12 goals this season.
"The medical team at Thorp Arch are confident that Rodrigo will return to play by the end of March," said Leeds.
Rodrigo has scored 10 of Leeds' 26 Premier League goals so far this campaign and is the top flight's fifth top scorer.
Jesse Marsch's side, who are 15th in the table, one point above the relegation zone, travel to Nottingham Forest on Sunday.