Gabriel Jesus is the latest Manchester City star struck down by injury, leaving teenager Liam Delap their only recognised striker.
Brazil announced on Friday that Jesus had been withdrawn from next month's World Cup qualifiers after suffering a problem during Monday's win at Wolves.
Guardiola's injury problems have deepened, with the manager claiming he has just 13 senior professionals available for Sunday's home clash with Leicester City.
Delap, 17, is in contention to make a Premier League debut after scoring on his professional bow during Thursday night's 2-1 Carabao Cup third round victory over Bournemouth.