Defender Jonny Evans, who has a hamstring injury, is one of nine Leicester players unavailable due to a combination of injury, illness and Covid-19.
Caglar Soyuncu is the other new absentee from their win at Newcastle but Daniel Amartey is fit.
Tottenham's past two matches have been postponed because of a Covid-19 outbreak.
They had just 16 first-team players available for training on Wednesday.
LAWRO'S PREDICTION
Leicester are very difficult to predict at the moment because every time it looks as if they have got their spark back, they chuck in a poor performance.