Leicester winger Harvey Barnes is available for the first time this season after recovering from a knee injury.
Southampton forward Che Adams suffered a minor injury during last week's 2-2 draw with Leeds but returned to training on Thursday.
Romain Perraud, Tino Livramento and Theo Walcott remain on the sidelines.
CHRIS SUTTON'S PREDICTION
Southampton manager Ralph Hasenhuttl seems to be under a bit of pressure, which seems unfair so early in the season, so it was important for him that they came back from 2-0 down to draw with Leeds last time out.
Hasenhuttl had been tinkering with playing three at the back during pre-season, but he went back to a four against Leeds and I wouldn't be surprised to see him stick with that here.