Leicester City pair Jonny Evans and Wilfred Ndidi could both be involved.
Ndidi has overcome a hamstring injury, while Evans will be assessed before a decision is made on his return from a calf problem.
Manchester City will check on the fitness of Erling Haaland, who came off at half-time against Dortmund in midweek with a foot issue.
Manager Pep Guardiola is expected to give a full injury update during his press conference on Friday afternoon.
CHRIS SUTTON'S PREDICTION
This is tricky because, as I speak, I don't know if Erling Haaland will be fit to play.