Ademola Lookman scored the only goal as Leicester beat Liverpool to leave the Reds six points off the top of the Premier League table.
Liverpool's biggest chances came in the first half when Mohamed Salah had a 15th-minute penalty saved by Kasper Schmeichel and headed the rebound off the bar.
Sadio Mane then missed a couple of opportunities for Jurgen Klopp's side before they were made to pay by the hosts in the 59th minute.
Former Everton forward Lookman, with only his fourth touch after coming on, took Kiernan Dewsbury-Hall's pass in his stride, beat Joel Matip and rifled a shot past Alisson.