Leicester City boss Brendan Rodgers praised the "fitness and hunger" of Jamie Vardy after his superb finish for the Foxes meant Bruno Lage's Wolves tenure began with a defeat at King Power Stadium.
The Foxes' number nine was the most lively player on the pitch and struck just before half-time courtesy of a well-timed run and angled header from Ricardo Pereira's right-wing cross.
The 34-year-old, who netted 17 times last season including two on the final day against Tottenham, had earlier seen a finish from a tight angle ruled out for offside.
Rodgers admitted afterwards that his task now is to manage the striker correctly in order to ensure he maintains such impressive performances across the campaign.