Crystal Palace full-back Patrick van Aanholt has returned to training following an ankle injury and could be available to face Leicester.
James Tomkins is a doubt with a calf problem, while Scott Dann, Fraizer Campbell and Loic Remy are out.
Leicester captain Wes Morgan will miss a sixth straight match because of a back injury, although he may be fit to face Atletico Madrid on Tuesday.
Manager Craig Shakespeare will rest several key players ahead of that tie.
MOTD COMMENTATOR'S NOTES
Mark Scott: "A little over two months ago, Crystal Palace were second from bottom in the table, with Leicester lying just one place above the relegation zone.