Arsenal will assess Willian and Dani Ceballos, who were absent against Rapid Vienna with minor injuries, while Rob Holding is out with a hamstring strain.
Mesut Ozil and Sokratis have not been selected in the Gunners' Premier League squad, but Thomas Partey may start his first game in the English top flight.
Leicester will monitor Jamie Vardy, who has missed their last two league and cup games with a calf problem.
Ricardo Pereira, Caglar Soyuncu, Daniel Amartey and Wilfred Ndidi are injured.
Islam Slimani comes back into contention after being ineligible for Thursday's victory against Zorya Luhansk.