The Wildcats (19-8, 9-5 SEC) torched the nets at a pace of 41-for-65 (63%) from the field and 13-for-24 (54%) from the three-point line.
Kentucky led the Crimson Tide (19-8, 11-3) by as many as 37 points in the second half.
Justin Edwards led the Cats with a career-high 28 points on a perfect 10-for-10 from the field.
Antonio Reeves added 24 points and 5 assists. Zvonimir Ivisic added a career-high 18 points. Rob Dillingham chipped in 16.
Kentucky returns to action Tuesday night with an important road game at Mississippi State.