Kansas State trails Oklahoma State 27-22 after one half of basketball at Gallagher-Iba Arena.
The Cowboys built the advantage behind seven points from Jeff Newberry and six points from Tavarius Shine.
The Wildcats have been sloppy from the start, losing 11 turnovers.
D.J. Johnson leads K-State with six points, while Barry Brown has scored five.
K-State has lost 12 straight conference road games, and is attempting to end that streak.