White Sox left fielder Melky Cabrera, who was a triple shy of the cycle, went 4-for-4. He drove in the game's first two runs, but the Royals hit three home runs in the sixth inning off left-hander David Holmberg to take the lead.
After White Sox starter Mike Pelfrey walked Lorenzo Cain to start the inning, Holmberg entered and got Eric Hosmer to line out.