Yost made his managerial debut with the Milwaukee Brewers in 2003, where he stayed until 2008. During his time with the organization, he accrued his first 457 wins, with his best seasons coming in 2007 and 2008, when his club won a total of 83 games both years. Yost finished his tenure in 2008 with a record of 457-502 (.477).
Kansas City Royals fans will always remember the makeover that Dayton Moore washed over Kauffman Stadium and the Royals clubhouse. With the addition of Ned Yost for the 2010 season, he and Royals fans alike were hopeful for the future of their Kansas City team.