When things kick off between the Kansas City Chiefs and Arizona Cardinals on Sunday afternoon, quarterback Patrick Mahomes will be throwing to players he never has before in a regular-season game.
Wide receivers like JuJu Smith-Schuster and Marquez Valdes-Scantling will see the most snaps at their position despite limited experience together (remember, Smith-Schuster did not get a preseason target from Mahomes).
Tight end Travis Kelce is still in Kansas City, representing the target Mahomes will naturally lean on the most in crucial situations. The chemistry they’ve built together is a weapon, but opposing defenses know that, too.