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Jaguars vs Bills: Week 3 opening odds

The Jacksonville Jaguars (0-2) will face the Buffalo Bills (2-0) at 1:00 p.m. EST on Monday, September 23 at Highmark Stadium. It’s the first leg of a Monday Night Football doubleheader — the Washington Commanders play the Cincinnati Bengals at 8:15 p.m. at Paycor Stadium.

According to FanDuel Sportsbook, the Jaguars are 5.5-point underdogs and the total is set at 46.5 points.

The Jaguars are 10-9 against the Bills all time, including 3-1 in the last four matchups and 2-0 in the last two. It’ll be the first game that Josh Hines-Allen, previously known as Josh Allen, faces off against Buffalo quarterback Josh Allen with his new name.