After three straight weeks at home, the Jacksonville Jaguars head west in week 16 to take on the San Francisco 49ers. The Jaguars enter the game at 10-4, and having already clinched a spot in the postseason for the first time since 2007. The 49ers enter at 4-10, but all four wins have come in the last five weeks.
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Jacksonville can clinch the AFC South with a win, but the division title may already be locked up before the teams even kick off, with the Tennessee Titans having to face the Los Angeles Rams at 1:00.