are an enigma. They get blown out by Geno Smith. They put together an elite defensive performance against Josh Allen. They tear through a Cincinnati Bengals (-1.5) defense that (at the time) was good... only to look like a junior varsity squad against the Indianapolis Colts (+7).
Should be a fun afternoon!
Here’s everything you need to know to watch, listen, and follow the game. Want to make today even more interesting? See more info on DraftKings Sportsbook’s odds here
Everything you need to know
- Location: TIAA Bank Field, Jacksonville, Florida
- Playing surface: Grass
- Game time: 1:00pm EST, Sunday, November 21, 2021
- Weather forecast: Cloudy, high of 75, winds 10mph
- Matchup history: 49ers lead 3-2
- Odds: Colts -9 with an over/under set at 44.