Mauricio Pochettino's side will be looking to bounce back from their north London derby defeat by piling the misery on a struggling Saints team
Tottenham will look to bounce back from their loss in the north London derby with a game against relegation candidates Southampton.
Spurs were comprehensively beaten 4-2 by Arsenal at the weekend at the Emirates whilst Southampton threw away a two-goal lead to draw with Manchester United.
The Saints appointed former RB Leipzig manager Ralph Hasenhuttl prior to the game but not in time to take full charge.
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The new boss will be in the stands, so the Southampton players should be looking to impress their new boss.