Spartak Moscow and Lille were the high-profile casualties of Europa League qualifying, losing to Larnaca and Qabala, respectively.
Russian Premier League giant Spartak Moscow was dumped out of the Europa League qualifiers after a shock defeat to Larnaca.
Spartak, quarterfinalist in the competition as recently as 2011 and 21-time champion of Russia, suffered a 1-0 home defeat to last season's runner-up in the Cypriot top flight thanks to Ivan Trickovski's 89th-minute goal.
The result gave Lanarca a 2-1 aggregate victory to send it into Friday's draw for the playoff round.
Lille, which welcomed back Portugal's Euro 2016 hero Eder, was stunned by Azerbaijan outfit Qabala, which sealed a 2-1 aggregate win thanks to a 1-0 victory on home soil.