The 29-year-old played in over 120 professional games since debuting for the Philadelphia Union in 2011.
Seattle Sounders midfielder Michael Farfan announced his retirement in a Facebook post on Friday.
The 29-year-old, who made one league appearance with the Sounders last season, had also featured in MLS for D.C. United and the Philadelphia Union. It was in Philadelphia where he made the most impact, having made 85 league apearances and scoring four times with the Union.
Farfan also had a brief stint in Liga MX, where he made a single 12-minute appearance for Cruz Azul in the 2013-14 campaign.