Uruguay were rudderless after Edinson Cavani's early departure in Dublin, where they slumped to a 3-1 defeat against Republic of Ireland.
Goals from Jonathan Walters, Cyrus Christie and James McClean gave Republic of Ireland a 3-1 win over Uruguay after Paris Saint-Germain star Edinson Cavani limped off in Dublin.
Uruguay were already operating without Luis Suarez and Diego Godin, and Oscar Tabarez's experimental line-up was unsettled by the early withdrawal of Cavani, who decided he was unable to continue shortly after a collision with Kevin Long.
Ireland were good value for taking the lead before the half-hour mark, when Walters finished superbly from 20 yards, but the Stoke forward went from hero to villain in first-half stoppage time when, after Atletico Madrid defender Jose Gimenez headed an equaliser, he hit the crossbar from close range with the goal gaping.