Four changes in total from Gennaro Gattuso, with Milik, Lobotka, Ruiz and Kostas Manolas dropping out from the side which beat Torino at the end of February. Mertens, Demme, Elmas and Koulibaly have come in.
NAPOLI (4-3-3): David Ospina; Giovanni Di Lorenzo, Nikola Makisimovic, Kalidou Koulibaly, Elseid Hysaj; Eljif Elmas, Diego Demme, Piotr Zielinski; Matteo Politano, Dries Mertens, Lorenzo Insigne.
Fabian Ruiz scored a sublime winner at San Siro in the first leg, with Napoli then going another four matches unbeaten in all competitions before competitions were halted in March. Inter, meanwhile, have lost three of their last five fixtures.